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Chronic ischemic heart disease was the exception and had an unadjusted lower risk in the candesartan group (0.

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Other secondary end points included the progression of renal disease and changes in the level of proteinuria.

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ACE) inhibitors, angiotensin-receptor blockers, and calcium-channel blockers were discontinued at least 10 days before the screening period, during which time blood pressure was controlled with other agents.

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Changes of losartan and candesartan doses during follow-up.

Similar reductions in mean ambulatory DBP and SBP were seen after treatment with olmesartan and irbesartan.

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The volume of distribution of losartan and the active metabolite is about 34 liters and 12 liters, respectively.

However, data are accumulating to support their use in patients with congestive heart failure, especially patients who cannot tolerate ACE inhibitors.

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This finding in patients without clinical heart failure at base line accords well with findings from the Studies of Left Ventricular Dysfunction Prevention study.

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Vasodilatation of arteriolar resistance vessels and venous capacitance vessels effectively unloads the heart, reduces LV wall stress, relieves coronary artery constriction, and redistributes flow through collaterals to reduce myocardial ischemia.

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Careful re-evaluation of the impact of stopping inhibitors of the renin-angiotensin system in patients with advanced chronic kidney disease.

In addition, we assessed the effects of losartan and placebo on the following secondary end points: a composite of morbidity and mortality from cardiovascular causes, proteinuria, and the rate of progression of renal disease.

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The bioavailability of the suspension formulation was compared with losartan tablets in healthy adults.

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Some researchers worried that publishing the data might doom efforts to persuade parents to enroll children in the trial when they could get a drug like losartan on their own.

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Losartan pharmacokinetics have been investigated in the elderly (65 to 75 years) and in both genders.

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Patients were randomized to receive losartan potassium 50 mg once daily or placebo on a background of conventional antihypertensive therapy excluding ACE inhibitors and angiotensin II antagonists.

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