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Ursodiol is the best medication on the market for biliary cirrhosis treatment. I have been a sufferer of primary biliary cirrhosis for more than six years when I was first prescribed with Ursodiol about a year ago. A few weeks later I have undergone a comprehensive testing and the results indicated that my AMA was negative! Then my doctor decided to put me off Ursodiol and see what happens. But the observations showed it was too early to stop taking Ursodiol so I'm on it again and it still helps. In general the medication is fantastic. Hope I'll be able to cope without it soon.

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The follow-up consists of 4 MRI controls of the abdomen using the hepatocyte-specific contrast agent Gd-EOB-DTPA (Primovist) after 3 days, 6 weeks, 3 months and 6 months as well as blood samples and a questionnaire taken the same time.

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Although the exact mechanism of ursodiol's anticholelithic action is not completely understood, it is known that when administered orally ursodiol is concentrated in bile and decreases biliary cholesterol saturation by suppressing hepatic synthesis and secretion of cholesterol, and by inhibiting its intestinal absorption.

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