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This case series includes the first 5 patients placed on topiramate treatment either as outpatients or in the inpatient setting.

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If they recognize that this is not working, a triptan is used as rescue therapy.

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If metabolic acidosis develops (it may be corrected by administration of sodium bicarbonate), and persists, a dose reduction or treatment discontinuation should be considered.

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This therapy is continued every 8 hours till headache freedom, with a maximum of 20 doses.

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